As the most effective and economical means to prevent and control the infection of the SARS-CoV-2, the R&D and application of the COVID-19?vaccine have always attracted much attention. The development of the COVID-19?vaccine has applied a variety of technical routes, namely inactivated vaccines, recombinant protein vaccines, adenovirus vector vaccines, attenuated influenza virus vector vaccines, and nucleic acid vaccines.

Insect cell baculovirus expression vector system (IC-BEVS) is one of the four major expression systems (insect cell, bacterial, yeast and mammalian cell expression systems).